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GW-311616A

A potent, selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor
Catalog #: B2559
SKU-Size Size Price Qty
B2559-1 1 mg
$85.00
B2559-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl) hexahydropyrrolo [3,2-b]pyrrol-2(1H)-one hydrochloride, GW311616 hydrochloride
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 197890-44-1
Molecular Formula C₁₉H₃₁N₃O₄S . HCl
Molecular Weight 434.0
Purity ≥98% by HPLC
Solubility in DMSO, in Water
SMILES CC(C)C1C2C(CCN2C(=O)C=CCN3CCCCC3)N(C1=O)S(=O)(=O)C.Cl
InChi InChI=1S/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8, 14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17+,18-;/m1./s1
InChi Key UFCZUKYPBPXODT-OFTZGUNKSA-N
PubChem CID 9889108
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GW-311616 is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.


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