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Product Details
| Alternate Name | 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide; GSK429286 |
|---|---|
| Appearance | White solid |
| CAS # | 864082-47-3 |
| Molecular Formula | C₂₁H₁₆F₄N₄O₂ |
| Molecular Weight | 432.27 |
| Purity | >98% by HPLC |
| Solubility | DMSO (~40 mg/ml) or EtOH (~10 mg/ml) |
| SMILES | CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F |
| InChi | nChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31) |
| InChi Key | OLIIUAHHAZEXEX-UHFFFAOYSA-N |
| PubChem CID | 11373846 |
| MDL Number | MFCD16618404 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency.
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