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A potent and selective Rho-kinase (ROCK) inhibitor
Catalog #: 2637
SKU-Size Size Price Qty
2637-1 1 mg
2637-5 5 mg
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Product Details

Alternate Name 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide; GSK429286
Appearance White solid
CAS # 864082-47-3
Molecular Formula C₂₁H₁₆F₄N₄O₂
Molecular Weight 432.27
Purity >98% by HPLC
Solubility DMSO (~40 mg/ml) or EtOH (~10 mg/ml)
SMILES CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F
InChi nChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)
PubChem CID 11373846
MDL Number MFCD16618404
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency.

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