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Apotent and selective LRRK2 inhibitor
Catalog #: 2845
SKU-Size Size Price Qty
2845-5 5 mg
2845-25 25 mg
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Product Details

Alternate Name 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
Appearance White solid
CAS # 1285515-21-0
Molecular Formula C₂₄H₁₈FN₃O₂
Molecular Weight 399.42
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
InChi InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
PubChem CID 68107965
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows selectivity for LRRK2 against a panel of 460 other kinases. GSK2578215A displays good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.

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