Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A potent EZH2 inhibitor
Catalog #: 2282
SKU-Size Size Price Qty
2282-1 1 mg
2282-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name (S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
Peptide Sequence No
Appearance Crystalline solid
CAS # 1346574-57-9
Molecular Formula C₃₁H₃₈N₆O₂
Molecular Weight 526.67
Purity 100% by chiral HPLC & >99% by HPLC
Solubility DMSO (~50 mg/ml)
InChi InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1
PubChem CID 68210102
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and multiple other protein classes, even 150-fold more selective for the closest EZH1 (Kiapp = 89 nM) and more than 1,000-fold selective for 20 other human methyltransferases, including both SET-domain-containing and non-SET domain-containing methyltransferases. It decreases global H3K27me3 levels and reactivates silenced polycomb repressive complex 2 (PRC2) target genes.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Jung Kim, Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator. Cell Rep., Dec 2018;   30517868.
For more citations of this product click here