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GSK-LSD1 dihydrochloride

A potent and selective lysine specific demethylase 1 (LSD1)inhibitor
Catalog #: B1258
SKU-Size Size Price Qty
B1258-5 5 mg
B1258-25 25 mg
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Product Details

Alternate Name N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride
Peptide Sequence N/A
Appearance White to off-white solid
Formulation N/A
CAS # 1431368-48-7 (free base)
Molecular Formula C14H22Cl2N2
Molecular Weight 289.24
Purity ≥98% by HPLC
Solubility H₂O (>20 mg/ml)
InChi InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
PubChem CID 71522234
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 2HCl irreversibly inhibits LSD1 with IC₅₀ value of 16 nM and is > 1000 fold selective over LSD2, MAO-A and MAO-B, which were related to FAD utilizing enzymes.  GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns.

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