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GSK-J5 (hydrochloride)

An isomer of GSK-J4 and a prodrug for neagtive control GSK-J2
Catalog #: B2841
SKU-Size Size Price Qty
B2841-1 1 mg
B2841-5 5 mg
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Product Details

Alternate Name N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine, ethyl ester, monohydrochoride; ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride
Appearance A crystalline solid
CAS # 1797983-32-4
Molecular Formula C₂₄H₂₈ClN₅O₂
Molecular Weight 454
Purity ≥95%
Solubility ~20 mg/ml in Ethanol
~30 mg/ml in DMSO and DMF
InChi InChI=1S/C24H27N5O2.ClH/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29;/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28);1H
PubChem CID 126456082
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.


GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not have any effect on TNF-α protein production that depends on both JMJD3 and UTX. GSK-J5 is a weak inhibitor of JMJD3.

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