GSK-J4 hydrochloride

Histone demethylase JMJD3/UTX inhibitor
Catalog #: 2259 | abID:

Product Details

Alternate Name Ethyl 3-​((6-​(4,​5-​dihydro-​1H-​benzo[d]azepin-​3(2H)-​yl)-​2-​-(pyridin-2- yl)pyrimidin-4-yl)amino)propanoate, monohydrochloride
Peptide Sequence No
Appearance White to off-white solid
Molecular Formula C₂₄H₂₇N₅O₂ ∙ HCl
Molecular Weight 454
Purity ≥95%
Solubility DMSO
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (Cat. No. 2260-1, 5) (IC₅₀> 50 μM in vitro. When administered to human primary macrophages, GSK-J4 can reduce lipopolysaccharide (LPS)-induced proinflammatory cytokine production, most notably including that of TNFα (IC₅₀ = 9 µM).

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