Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

GSK-J4 (Free base)

A histone demethylase JMJD3/UTX inhibitor
Catalog #: 2762
SKU-Size Size Price Qty
2762-1 1 mg
$65.00
2762-5 5 mg
$195.00
More Sizes Get Quote

Product Details

Alternate Name N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Appearance Yellow waxy solid
CAS # 1373423-53-0
Molecular Formula C₂₄H₂₇N₅O₂
Molecular Weight 417.5
Purity ≥99% by TLC
Solubility DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)
SMILES CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
InChi InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChi Key WBKCKEHGXNWYMO-UHFFFAOYSA-N
PubChem CID 71729975
MDL Number MFCD22683852
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.