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GSK-J4 (Free base)

A histone demethylase JMJD3/UTX inhibitor
Catalog #: 2762
SKU-Size Size Price Qty
2762-1 1 mg
2762-5 5 mg
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Product Details

Alternate Name N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Appearance Yellow waxy solid
CAS # 1373423-53-0
Molecular Formula C₂₄H₂₇N₅O₂
Molecular Weight 417.5
Purity ≥99% by TLC
Solubility DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)
InChi InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
PubChem CID 71729975
MDL Number MFCD22683852
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

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