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GSK-J2 (Sodium Salt)

A negative control for in vitro studies with GSK-J1
Catalog #: B2813
SKU-Size Size Price Qty
B2813-1 1 mg
B2813-5 5 mg
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Product Details

Alternate Name 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt, 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid;sodium
Appearance Crystalline solid
CAS # 2108665-15-0
Molecular Formula C₂₂H₂₃N₅NaO₂
Molecular Weight 411.43
Purity ≥90%
Solubility Sparingly soluble in aqueous and organic solvents such as DMSO, ethanol and DMF
InChi InChI=1S/C22H23N5O2.Na/c28-21(29)7-11-24-19-14-20(26-22(25-19)18-6-3-10-23-15-18)27-12-8-16-4-1-2-5-17(16) 9-13-27;/h1-6,10,14-15H,7-9,11-13H2,(H,28,29)(H,24,25,26);
PubChem CID 137699749
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits JMJD3 with an IC₅₀ > 100 μM in vitro. GSK-J2 serves as a negative control for in vitro studies with GSK-J1.

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