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GSK-J1 sodium salt

A potent histone demethylase JMJD3/UTX inhibitor
Catalog #: 2260
SKU-Size Size Price Qty
2260-1 1 mg
2260-5 5 mg
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Product Details

Alternate Name 3-​((6-​(4,​5-​dihydro-​1H-​benzo[d]azepin-​3(2H)-​yl)-​2-​(pyridin-​2-​yl)pyrimidin-4-yl)amino)propanoate, monosodium salt
Peptide Sequence No
Appearance Crystalline solid
Molecular Formula C₂₂H₂₂N₅O₂ ∙ Na
Molecular Weight 411.43
Purity ≥95%
Solubility DMSO
PubChem CID
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.

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