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GSK-923295

An allosteric inhibitor of CENP-E kinesin motor ATPase
Catalog #: B3104
SKU-Size Size Price Qty
B3104-5 5 mg
$240.00
B3104-1 1 mg
$60.00
More Sizes Get Quote

Product Details

Alternate Name 3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide; 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide ; 3-Chloro-N-((S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide; GSK923295A
Appearance White to off-white powder
CAS # 1088965-37-0
Molecular Formula C₃₂H₃₈ClN₅O₄
Molecular Weight 592.13
Purity ≥ 97%
Solubility ~30 mg/ml in DMSO
SMILES CC(C)OC1=C(C=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)C3=CN4C=CC=C(C4=N3)C(C)O)CNC(=O)CN(C)C)Cl
InChi InChI=1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34,40)(H,35,41)/t21-,25-/m0/s1
InChi Key WHMXDBPHBVLYRC-OFVILXPXSA-N
PubChem CID 46898058
MDL Number MFCD16038931
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK923295 is an allosteric inhibitor of CENP-E kinesin motor ATPase activity. It inhibits CENP-E microtubule-stimulated ATPase activity with a Ki of 3.2 ± 0.2 nM. It inhibits the growth of tumor cell lines with growth inhibitory activity (GI₅₀) values ranging from 12 nM to greater than 10,000 nM.


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