Product Details
| Alternate Name | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol |
|---|---|
| Appearance | Yellow solid |
| CAS # | 937174-76-0 |
| Molecular Formula | C₂₁H₂₇N₇O₃ |
| Molecular Weight | 425.48 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~20 mg/ml) |
| SMILES | CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
| InChi | InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 |
| InChi Key | KGPGFQWBCSZGEL-ZDUSSCGKSA-N |
| PubChem CID | 16725726 |
| MDL Number | MFCD14105605 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
An ATP-competitive pan-Akt kinase inhibitor. Inhibits Akt kinase isoforms 1, 2, 3 with IC₅₀ values of 2, 13, and 9 nM, respectively. Inhibited proliferation and induced apoptosis in a subset of tumor cells with potency consistent with intracellular inhibition of Akt kinase activity.
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Yichun Zhu. Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells. J Transl Med May-19. 31072323.
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