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GSK-690693

A pan-Akt kinase inhibitor
Catalog #: 2272
SKU-Size Size Price Qty
2272-5 5 mg
$125.00
2272-25 25 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)­-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[­4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Appearance Yellow solid
CAS # 937174-76-0
Molecular Formula C₂₁H₂₇N₇O₃
Molecular Weight 425.48
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
InChi InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChi Key KGPGFQWBCSZGEL-ZDUSSCGKSA-N
PubChem CID 16725726
MDL Number MFCD14105605
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An ATP-competitive pan-Akt kinase inhibitor. Inhibits Akt kinase isoforms 1, 2, 3 with IC₅₀ values of 2, 13, and 9 nM, respectively. Inhibited proliferation and induced apoptosis in a subset of tumor cells with potency consistent with intracellular inhibition of Akt kinase activity.


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Yichun Zhu. Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells. J Transl Med May-19. 31072323.
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