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A potent inhibitor of serum- and glucocorticoid-regulated kinase
Catalog #: B2093
SKU-Size Size Price Qty
B2093-5 5 mg
B2093-25 25 mg
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Product Details

Alternate Name 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Appearance Crystalline solid
CAS # 890842-28-1
Molecular Formula C₂₅H₂₂N₂O₂
Molecular Weight 382.45
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
PubChem CID 25022668
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-650394 is a potent inhibitor of serum- and glucocorticoid-regulated kinase (IC₅₀s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases. GSK-650394 can inhibit the androgen-stimulated growth of human prostate carcinoma LNCaP cells with an IC₅₀ value of ~ 1 μM.

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