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GSK-5959

A potent and selective BRPF1 bromodomain inhibitor
Catalog #: B2343

In stock

SKU-Size Size Price Qty
B2343-5 5 mg
$85.00
B2343-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide,GSK5959
Appearance Pale yellow solid
CAS # 901245-65-6
Molecular Formula C₂₂H₂₆N₄O₃
Molecular Weight 394.47
Purity ≥98% by HPLC
Solubility ~4 mg/ml (DMSO)
SMILES CN1C2=CC(=C(C=C2N(C1=O)C)N3CCCCC3)NC(=O)C4=CC=CC=C4OC
InChi InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6,9-10,13-14H,4,7-8,11-12H2,1-3H3,(H,23,27)
InChi Key LTUGYAOMCKNTGG-UHFFFAOYSA-N
PubChem CID 15990224
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.


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