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GSK-3a Antibody

Catalog #: 3493
$265.00

Product Details

Cat # +Size 3493-100
Size 100 µg
Antibody Target GSK-3a
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide from human GSK-3alpha
Accession # NP_063937.2
Gene ID 49574532
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity-purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blotting, Immunoprecipitation, Immunohistochemistry
Application & Usage Western blot analysis (1-2 µg/ml) and Immunohistochemistry (20-30 µg/ml). However, the optimal conditions should be determined individually. The antibody detects GSK-3 from human, mouse, & rat origin; non cross-reactive with GSK-3β.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways, and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has also been implicated in alzheimer’s disease. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3.


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