Product Details
| Cat # +Size | 3493-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | GSK-3a |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide from human GSK-3alpha |
| Accession # | NP_063937.2 |
| Gene ID | 49574532 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 100 µg (0.2 mg/ml) affinity-purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blotting, Immunoprecipitation, Immunohistochemistry |
| Application & Usage | Western blot analysis (1-2 µg/ml) and Immunohistochemistry (20-30 µg/ml). However, the optimal conditions should be determined individually. The antibody detects GSK-3 from human, mouse, & rat origin; non cross-reactive with GSK-3β. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways, and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has also been implicated in alzheimer’s disease. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3.
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