A potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C
Catalog #: B1939 | abID:

Product Details

Alternate Name 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea
Appearance Crystalline solid
CAS # 942918-07-2
Molecular Formula C₃₀H₃₃N₇O
Molecular Weight 507.63
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
InChi InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38)
PubChem CID 46885626
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-1070916 is a potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C with IC₅₀ value of 3.5 nM and 6.5 nM, respectively. Treatment of GSK-1070916 suppresses cell proliferation in A549 human lung cancer cells with EC₅₀ value of 7 nM. 

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