Product Details
| Alternate Name | N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1047644-62-1 |
| Molecular Formula | C₁₈H₁₇Cl₂FN₄OS |
| Molecular Weight | 427.32 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>10 mg/ml) |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl |
| InChi | InChI=1S/C18H16Cl2F2N4OS/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1 |
| InChi Key | AHDFWNJLFALBJP-JTQLQIEISA-N |
| PubChem CID | 57826797 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.
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