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A potent protein arginine methyltransferase 5 inhibitor
Catalog #: B3321
SKU-Size Size Price Qty
B3321-5 5 mg
B3321-25 25 mg
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Product Details

Alternate Name Pemrametostat EPZ-015938 S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide
Appearance Crystalline solid
CAS # 1616392-22-3
Molecular Formula C₂₄H₃₂N₆O₃
Molecular Weight 452.56
Purity ≥98% by HPLC
Solubility >25 mg/ml DMSO
InChi InChI=1S/C24H32N6O3/c1-17(31)30-10-7-20(8-11-30)28-23-12-22(26-16-27-23)24(33)25-13-21(32)15-29-9-6-18-4-2-3-5-19(18)14-29/h2-5,12,16,20-21,32H,6-11,13-15H2,1H3,(H,25,33)(H,26,27,28)/t21-/m0/s1
PubChem CID 90241742
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-3326595 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 6.2 nM) that induces cell death in a broad range of solid and hematologic tumor cell lines. It also displays potent anti-tumor activity in vivo in animal models, including in preclinical models of myeloid malignancies

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