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A potent and selective DYRK inhibitor
Catalog #: B2452
SKU-Size Size Price Qty
B2452-5 5 mg
B2452-25 25 mg
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Product Details

Alternate Name (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
Appearance Pale orange solid
CAS # 1025821-33-3
Molecular Formula C₁₈H₁₀Cl₂N₄OS
Molecular Weight 401.27
Purity ≥98% by HPLC
Solubility >35 mg/ml DMSO
SMILES C1=CC(=C(C(=C1)Cl)N=C2NC(=O)C(=CC3=CC4=NC=CN=C4C=C3)S2)Cl
InChi InChI=1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
PubChem CID 135416229
MDL Number MFCD31689261
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-626616 is a potent and selective DYRK inhibitor (IC₅₀ = 0.7 nM); inhibits other members of the DYRK family, e.g., DYRK1A and DYRK2, with similar potency. Displays ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened.

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