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A potent and selctive PERK (protein kinase R-like ER kinase) inhibitor
Catalog #: 9467
SKU-Size Size Price Qty
9467-5 5 mg
9467-25 25 mg
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Product Details

Alternate Name 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone
Appearance White solid
CAS # 1337531-36-8
Molecular Formula C₂₄H₂₀F₃N₅O
Molecular Weight 451.44
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
InChi InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
PubChem CID 53469448
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-2606414 is a potent and selective inhibitor of protein kinase R-like ER kinase (PERK) with IC₅₀ value of 0.4 nM. Displays >1000-fold selectivity for PERK over HR1 and PKR. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice.

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