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GSK-2656157

A potent and selctive PERK (protein kinase R-like ER kinase) inhibitor
Catalog #: 9466
SKU-Size Size Price Qty
9466-5 5 mg
$125.00
9466-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone
Appearance White solid
CAS # 1337532-29-2
Molecular Formula C₂₃H₂₁FN₆O
Molecular Weight 416.45
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C
InChi InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
InChi Key PRWSIEBRGXYXAJ-UHFFFAOYSA-N
PubChem CID 53469059
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel of 300 kinases (IC₅₀>100 nM).


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Isabelle C. Romine, PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress. Sci Rep, Jan 2019; 30675021.
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