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GSK-583

A highly potent and selective Inhibitor of RIP2 Kinase
Catalog #: B1301
SKU-Size Size Price Qty
B1301-5 5 mg
$135.00
B1301-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine
Appearance Crystalline solid
CAS # 1346547-00-9 
Molecular Formula C₂₀H₁₉FN₄O₂S
Molecular Weight 398.46
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
InChi InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChi Key XLOGLWKOHPIJLV-UHFFFAOYSA-N
PubChem CID 67469084
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-583 is a highly potent and selective Inhibitor of RIP2 Kinase (IC₅₀ = 5 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.


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