Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A highly potent and selective Inhibitor of RIP2 Kinase
Catalog #: B1301
SKU-Size Size Price Qty
B1301-5 5 mg
B1301-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine
Appearance Crystalline solid
CAS # 1346547-00-9 
Molecular Formula C₂₀H₁₉FN₄O₂S
Molecular Weight 398.46
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
InChi InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
PubChem CID 67469084
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK-583 is a highly potent and selective Inhibitor of RIP2 Kinase (IC₅₀ = 5 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.