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GSK-2110183

A potent, selective, and ATP-competitive pan-Akt inhibitor
Catalog #: B1089
SKU-Size Size Price Qty
B1089-1 1 mg
$125.00
B1089-5 5 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide
Appearance Crystalline solid
CAS # 1047644-62-1
Molecular Formula C₁₈H₁₇Cl₂FN₄OS
Molecular Weight 427.32
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl
InChi InChI=1S/C18H16Cl2F2N4OS/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
InChi Key AHDFWNJLFALBJP-JTQLQIEISA-N
PubChem CID 57826797
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.


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