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Product Details
| Alternate Name | N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea |
|---|---|
| Appearance | Off-white solid |
| CAS # | 487021-52-3 |
| Molecular Formula | C₁₂H₁₂N₄O₄S |
| Molecular Weight | 308.31 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (30 mg/ml) |
| SMILES | COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-] |
| InChi | InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17) |
| InChi Key | YAEMHJKFIIIULI-UHFFFAOYSA-N |
| PubChem CID | 448014 |
| MDL Number | MFCD08277040 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
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