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GSK-3 Inhibitor, AR-A014418

A selective GSK-3 inhibitor
Catalog #: 1953
SKU-Size Size Price Qty
1953-2 2 mg
$70.00
1953-5 5 mg
$135.00
More Sizes Get Quote

Product Details

Alternate Name N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Appearance Off-white solid
CAS # 487021-52-3
Molecular Formula C₁₂H₁₂N₄O₄S
Molecular Weight 308.31
Purity ≥98% by TLC
Solubility DMSO (30 mg/ml)
SMILES COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChi InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
InChi Key YAEMHJKFIIIULI-UHFFFAOYSA-N
PubChem CID 448014
MDL Number MFCD08277040
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.


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