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GSK-269962 hydrochloride

A potent and selective Rho Kinase (ROCK) inhibitor
Catalog #: B2425
SKU-Size Size Price Qty
B2425-5 5 mg
$155.00
B2425-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name GSK269962, GSK26996B, GSK-269962A, N-[3-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide hydrochloride
Appearance Crystalline solid
CAS # 2095432-71-4
Molecular Formula C₂₉H₃₁ClN₈O₅
Molecular Weight 607.07
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl
InChi InChI=1S/C29H30N8O5.ClH/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22) 32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36;/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38);1H
InChi Key UYKVMFKKKLLDGL-UHFFFAOYSA-N
PubChem CID 57398146
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-269962 is a potent and selective Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). It displays >30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC₅₀ = 35 nM) and lowers blood pressure in a rat model of hypertension.


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