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GSK-2118436 mesylate

A selective BRAF V600E inhibitor
Catalog #: 2800
SKU-Size Size Price Qty
2800-5 5 mg
2800-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, methanesulfonic acid; Dabrafenib Mesylate
Appearance White to off-white solid
CAS # 1195768-06-9
Molecular Formula C₂₄H₂₄F₃N₅O₅S₃
Molecular Weight 615.67
Purity ≥98% by HPLC
Solubility DMSO
SMILES O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O.CS(O)(=O)=O
InChi InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)
PubChem CID 44516822
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild type B-Raf and c-Raf with IC₅₀s of 3.2 nM and 5.0 nM, respectively.

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