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GSK-1120212

based on 1 citations in multiple journalsGSK-112021214.1 4
A potent and selective allosteric MEK1 inhibitor
Catalog #: 1960
SKU-Size Size Price Qty
1960-1 1 mg
$80.00
1960-5 5 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057; Trametinib
Appearance Off-white solid
CAS # 871700-17-3
Molecular Formula C₂₆H₂₃FIN₅O₄
Molecular Weight 615.39
Purity ≥98% by HPLC
Solubility DMSO (~ 10 mg/ml)
SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
InChi InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChi Key LIRYPHYGHXZJBZ-UHFFFAOYSA-N
PubChem CID 11707110
MDL Number MFCD17215075
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9 nM) enzymes with potential antineoplastic activity.


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Kumar et al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J. Exp. Med.,  Apr 2014; 10.1084/jem.20131379.
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