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GSK-106 hydrochloride

A useful negative control for PAD4 inhibitors GSK-121 and GSK-484.
Catalog #: B1036
SKU-Size Size Price Qty
B1036-500 500 µg
$75.00
B1036-1000 1 mg
$125.00
More Sizes Get Quote

Product Details

Alternate Name (3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
Appearance Crystalline solid
CAS # 1652591-82-6
Molecular Formula C₂₄H₂₈ClN₅O
Molecular Weight 437.97
Purity ≥98%
Solubility DMSO (~30 mg/ml)
SMILES O=C(N1CC(N)CCC1)C2=CC=C3C(N(C)C(C(N4CC)=CC5=C4C=CC=C5)=N3)=C2.[H]Cl
InChi InChI=1S/C24H27N5O.ClH/c1-3-29-20-9-5-4-7-16(20)13-22(29)23-26-19-11-10-17(14-21(19)27(23)2)24(30)28-12-6-8-18(25)15-28;/h4-5,7,9-11,13-14,18H,3,6,8,12,15,25H2,1-2H3;1H
InChi Key VRPFLFUQMWOJAT-UHFFFAOYSA-N
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-106 is a useful negative control for PAD4 inhibitors (GSK-121 and GSK-484). It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 µM).


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