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GSK-1059615

A potent, reversible PI3Kα inhibitor
Catalog #: 9450
SKU-Size Size Price Qty
9450-5 5 mg
$115.00
9450-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 5Z-​[[4-​(4-​pyridinyl)-​6-​quinolinyl]methylene]-​2,​4-​thiazolidinedione
Appearance Off-white solid
CAS # 958852-01-2
Molecular Formula C₁₈H₁₁N₃O₂S
Molecular Weight 333.36
Purity ≥98% by HPLC
Solubility DMSO (~4 mg/ml)
SMILES C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4
InChi InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-
InChi Key QDITZBLZQQZVEE-YBEGLDIGSA-N
PubChem CID 23582824
MDL Number MFCD18074517
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.


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