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GSK-046

A potent BD2-selective inhibitor
Catalog #: B3270
SKU-Size Size Price Qty
B3270-5 5 mg
$135.00
B3270-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name iBET-BD2 4-Acetamido-3-fluoro-N-((1r,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide GSK046
Appearance Crystalline solid
CAS # 2474876-09-8
Molecular Formula C₂₃H₂₇FN₂O₄
Molecular Weight 414.47
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES CC(C1=CC=CC=C1)OC2=C(C(=CC(=C2)C(=O)NC3CCC(CC3)O)F)NC(=O)C
InChi InChI=1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18?,19?/m0/s1
InChi Key FRBRZGLUFOZRGD-YCMKEVRSSA-N
PubChem CID 146018690
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GSK-046 (iBET-BD2) is a potent and selective inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2BD2, BRD3BD2, BRD4BD2 and BRDTBD2, respectively. GSK-046 displays immunomodulatory activity.


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