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Product Details
| Alternate Name | BGH, BST, rBGH, rBST, Bovine Somatotropin, Bovine GH, Growth hormone, GH1. |
|---|---|
| Gene Symbol | GH1 |
| Gene ID | 280804 |
| Accession # | P01246 |
| Source | E. coli |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3 adjusted to pH 8-9. |
| Molecular Weight | 21.8 kDa |
| Purity by SDS-PAGE | 98% |
| Biological Activity | The activity as determined by the PDFP13B9 cells stably transfected with rabbit GH receptors. Bovine GH is also capable of forming a 1:2 complex with the recombinant ovine growth hormone receptor extracellular domain (ECD). |
| Reconstitution Instructions | It is recommended to reconstitute the lyophilized Bovine Growth Hormone in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Amino Acid Sequence | aa 1-191 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
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