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Growth Hormone, Bovine Recombinant

A protein which plays an important role in growth control
Catalog #: P1593
SKU-Size Size Price Qty
P1593-20 20 μg
$105.00
P1593-100 100 μg
$345.00
More Sizes Get Quote

Product Details

Alternate Name BGH, BST, rBGH, rBST, Bovine Somatotropin, Bovine GH, Growth hormone, GH1.
Gene Symbol GH1
Gene ID 280804
Accession # P01246
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3 adjusted to pH 8-9.
Molecular Weight 21.8 kDa
Purity by SDS-PAGE 98%
Biological Activity The activity as determined by the PDFP13B9 cells stably transfected with rabbit GH receptors. Bovine GH is also capable of forming a 1:2 complex with the recombinant ovine growth hormone receptor extracellular domain (ECD).
Reconstitution Instructions It is recommended to reconstitute the lyophilized Bovine Growth Hormone in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino Acid Sequence aa 1-191
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.


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