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Granzyme B Inhibitor Z-AAD-CH2Cl

based on 2 citations in multiple journalsGranzyme B Inhibitor Z-AAD-CH2Cl24.1 4
A granzyme B inhibitor
Catalog #: 1128
$145.00

Product Details

Cat # +Size 1128-20C
Size 20 µl (10 mM)
Alternate Name Z-AAD-CMK, Granzyme B Inhibitor(chloromethylketone)
Peptide Sequence Z-Ala-Ala-Asp(OMe)-CMK
Appearance Liquid
Formulation DMSO (10 mM)
Molecular Formula C₂₀H₂₆ClN₃O₇
Molecular Weight 455.89
Purity Single spot by TLC
SMILES CC(C(=O)NC(CC(=O)OC)C(=O)CCl)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C20H26ClN3O7/c1-12(19(28)24-15(16(25)10-21)9-17(26)30-3)22-18(27)13(2)23-20(29)31-11-14-7-5-4-6-8-14/h4-8,12-13,15H,9-11H2,1-3H3,(H,22,27)(H,23,29)(H,24,28)
InChi Key QMNQUIKZKYBZII-UHFFFAOYSA-N
PubChem CID 44135188
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits granzyme B activity. The inhibitor is designed as a methyl ester to facilitate cell permeability.


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Safta et al., Granzyme B–Activated p53 Interacts with Bcl-2 To Promote Cytotoxic Lymphocyte–Mediated Apoptosis. J. Immunol., Jan 2015; 194: 418 - 428.
Siegmund K et al (2009) J. Immunol.; 182: 2124 - 2130.
For more citations of this product click here