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Granzyme B, human recombinant (Insect)

A serine protease involved in CTL mediated apoptosis
Catalog #: 4728
$345.00

Product Details

Cat # +Size 4728-5
Size 5 μg
Alternate Name GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11
Gene Symbol Granzyme B
Gene ID 181186
Accession # AAA75490
Source Insect cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder from 0.22 μm filtered solution in PBS containing 8% trehalose
Molecular Weight 32 kDa
Purity by SDS-PAGE ≥90%
Biological Activity Activity of GZMB was tested using the synthetic peptide, IETD-AFC, as a substrate. GZMB releases AFC and then the GZMB activity can be quantified by fluorescent detection of free AFC at Ex/Em=380/500 nm.
Reconstitution Instructions Use 50 µl sterile D.I. water to dissolve 5 µg protein to a final conc of 0.1 µg protein/µl.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.


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