Granzyme B Antibody (Clone B18.1)

Catalog #: 3073 | abID:

Product Details

Cat # +Size 3073-100
Size 100 µg
Antibody Target Granzyme B
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG
Immunogen Human recombinant Granzyme B (a.a. 7-227)
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified mouse monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation, Immunohistochemistry, flow cytometry
Positive Control Human T-cells
Application & Usage Western blot, Immunoprecipitation, Immunohistochemistry, flow cytometry. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.


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