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Product Details
| Alternate Name | CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF |
|---|---|
| Gene Symbol | GZMA |
| Gene ID | 3001 |
| Accession # | P12544 |
| Source | HEK 293 cells |
| Appearance | Lyophilized protein |
| Physical Form Description | Recombinant Granzyme A is lyophilized from PBS |
| Molecular Weight | 26 kDa |
| Purity by SDS-PAGE | > 90% |
| Endotoxin Level | < 1.0 EU/μg of protein as determined by LAL method |
| Reconstitution Instructions | Reconstitute in sterile deionized water for a stock solution. |
| Amino Acid Sequence | Recombinant Human Granzyme A is expressed from HEK 293 cells. Target protein is expressed with sequence (Glu27-Val262) of Human granzyme A (Uniprot #P12544) fused with a C-terminal His tag. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | Aliquot and store at -20 °C or -80 °C. Avoid repeated freeze thaw cycles. |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Granzyme A is a member of the granzyme family. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28) and a mature chain (residues 29-262).
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