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Granzyme A, Human Recombinant

Serine proteases which induce apoptosis
Catalog #: 4279
SKU-Size Size Price Qty
4279-100 100 μg
$695.00
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Product Details

Alternate Name CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF
Gene Symbol GZMA
Gene ID 3001
Accession # P12544
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Recombinant Granzyme A is lyophilized from PBS
Molecular Weight 26 kDa
Purity by SDS-PAGE > 90%
Endotoxin Level < 1.0 EU/μg of protein as determined by LAL method
Reconstitution Instructions Reconstitute in sterile deionized water for a stock solution.
Amino Acid Sequence Recombinant Human Granzyme A is expressed from HEK 293 cells. Target protein is expressed with sequence (Glu27-Val262) of Human granzyme A (Uniprot #P12544) fused with a C-terminal His tag.
Handling Centrifuge the vial prior to opening.
Storage Conditions Aliquot and store at -20 °C or -80 °C. Avoid repeated freeze thaw cycles.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Granzyme A is a member of the granzyme family. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28) and a mature chain (residues 29-262).


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