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Granzyme A, human recombinant

Serine proteases which induce apoptosis
Catalog #: 4279

In stock

SKU-Size Size Price Qty
4279-10 10 μg
$225.00
4279-50 50 μg
$665.00
4279-1000 1 mg
$3,950.00
More Sizes Get Quote

Product Details

Alternate Name CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF
Gene Symbol GZMA
Gene ID 3001
Accession # P12544
Source Mammalian cell expression system
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 0.2 μm filtered solution of 20 mM MES and150 mM NaCl, pH 5.5.
Molecular Weight 26.9 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg (1 IEU/μg)
Reconstitution Instructions Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/ml.). This can further be diluted to other aqueous buffers.
Amino Acid Sequence Recombinant Human Granzyme A is produced with mammalian cells expression system. Target protein is expressed with sequence (Glu27-Val262) of Human granzyme a (Uniprot #P12544) fused with a polyhistidine tag at the C-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Granzyme A is a member of the granzyme family. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28) and a mature chain (residues 29-262).


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