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Gossypin

A potent antimelanoma agent
Catalog #: 2374
SKU-Size Size Price Qty
2374-50 50 mg
$85.00
2374-250 250 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 3,3',4',5,7,8-Hexahydroxyflavone-8-glucoside
Appearance Yellow solid
CAS # 652-78-8
Molecular Formula C₂₁H₂₀O₁₃
Molecular Weight 480.38
Purity ≥98% by HPLC
Solubility DMSO
SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O)O
InChi InChI=1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
InChi Key SJRXVLUZMMDCNG-KKPQBLLMSA-N
PubChem CID 5281621
MDL Number MFCD00017429
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A glucoside occurring in cotton and Hubiscus flowers that acts as a potent antimelanoma agent. Gossypin inhibits human melanoma cell proliferation, in vitro, in melanoma cell lines that harbors both BRAF-V600E kinase and CDK4 as well as in cells with BRAF wild-type allele. Gossypin inhibits the kinase activities of BRAF-V600E and CDK4, in vitro, possibly through direct binding with these kinases.


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