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Gö 6983

A broad-spectrum PKC inhibitor
Catalog #: 9539
SKU-Size Size Price Qty
9539-1 1 mg
$85.00
9539-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
Appearance Red solid
CAS # 133053-19-7
Molecular Formula C₂₆H₂₆N₄O₃
Molecular Weight 442.51
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
InChi InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChi Key LLJJDLHGZUOMQP-UHFFFAOYSA-N
PubChem CID 3499
MDL Number MFCD04040031
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Gö 6983 is a broad-spectrum Protein Kinase C (PKC) inhibitor; inhibits several isoforms of protein kinase C with IC₅₀ values of 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively). It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.


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