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Product Details
| Cat # +Size | 1711-500 |
|---|---|
| Size | 500 µg |
| Alternate Name | 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]py- rrolo[3,4-c]carbazole-12-propanenitrile; Go6976; PD 406976 |
| Appearance | Off-white to yellow solid |
| CAS # | 136194-77-9 |
| Molecular Formula | C₂₄H₁₈N₄O |
| Molecular Weight | 378.43 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O |
| InChi | InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
| InChi Key | VWVYILCFSYNJHF-UHFFFAOYSA-N |
| PubChem CID | 3501 |
| MDL Number | MFCD00236434 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). In vitro, discriminates between Ca²⁺-dependent and -independent isoforms of PKC; selectively inhibits PKCα and PKCβ1 (IC₅₀ values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKCδ, -ε, or -ζ (IC₅₀ > 3µM).
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