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Gö 6976

A PKC inhibitor
Catalog #: 1711

Product Details

Cat # +Size 1711-500
Size 500 µg
Alternate Name 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]py- rrolo[3,4-c]carbazole-12-propanenitrile; Go6976; PD 406976
Appearance Off-white to yellow solid
CAS # 136194-77-9
Molecular Formula C₂₄H₁₈N₄O
Molecular Weight 378.43
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
PubChem CID 3501
MDL Number MFCD00236434
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). In vitro, discriminates between Ca²⁺-dependent and -independent isoforms of PKC; selectively inhibits PKCα and PKCβ1 (IC₅₀ values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKCδ, -ε, or -ζ (IC₅₀ > 3µM).

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