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GNE-0877

An inhibitor of LRRK2
Catalog #: B2942
SKU-Size Size Price Qty
B2942-1 1 mg
$85.00
B2942-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 2-methyl-2-[3-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyrazol-1-yl]propanenitrile; α,α,3-trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile
Appearance A crystalline solid
CAS # 1374828-69-9
Molecular Formula C₁₄H₁₆F₃N₇
Molecular Weight 339.32
Purity 98.64%
Solubility ~15 mg/ml in DMSO, ~1 mg/ml in ethanol, ~10 mg/ml in DMF
SMILES CC1=NN(C=C1NC2=NC=C(C(=N2)NC)C(F)(F)F)C(C)(C)C#N
InChi InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
InChi Key ZPPUMAMZIMPJGP-UHFFFAOYSA-N
PubChem CID 69093374
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

GNE-0877 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with a Ki of 0.7 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-0877 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC₅₀ value of 3 nM.


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