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An inhibitor of LRRK2
Catalog #: B2943
SKU-Size Size Price Qty
B2943-1 1 mg
B2943-5 5 mg
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Product Details

Alternate Name 2-N-[5-chloro-1-[(3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]pyrazol-4-yl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
Appearance A crystalline solid
CAS # 1536200-31-3
Molecular Formula C₁₇H₂₀ClF₄N₇O
Molecular Weight 449.83
Purity 99.26%
Solubility ~20 mg/ml in DMSO, ~1 mg/ml in methanol
InChi InChI=1S/C17H20ClF4N7O/c1-23-15-10(17(20,21)22)4-24-16(27-15)26-12-5-25-29(14(12)18)13-2-3-28(6-11(13)19)9-7-30-8-9/h4-5,9,11,13H,2-3,6-8H2,1H3,(H2,23,24,26,27)/t11-,13-/m0/s1
PubChem CID 76328936
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC₅₀ of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation.

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