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Glycine N-methyltransferase, Human Recombinant

Regulate tissue concentration of AdoMet and metabolism of methionine.
Catalog #: P1235

In stock

SKU-Size Size Price Qty
P1235-10 10 μg
$105.00
P1235-50 50 μg
$315.00

Product Details

Alternate Name GNMT
Gene Symbol GNMT
Gene ID 27232
Accession # Q14749
Source E.coli
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Molecular Weight 34.9 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Specific activity > 100 nmol/min/mg
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IV
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Glycine N-methyltransferase, also known as GNMT, catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. This protein affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and participates in the detoxification pathway in liver cells. Also it is reported that GNMT expression is diminished in human hepatocellular carcinoma (HCC). Recombinant human GNMT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


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