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GLPG0634 Analog

A potent and selective JAK1 inhibitor
Catalog #: B1836
SKU-Size Size Price Qty
B1836-5 5 mg
$115.00
B1836-25 25 mg
$450.00
More Sizes Get Quote

Product Details

Alternate Name N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide; GLP-0634
Appearance Crystalline solid
CAS # 1206101-20-3 
Molecular Formula C₂₃H₁₈N₆O₂
Molecular Weight 410.44
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2
InChi InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)
InChi Key QZXABVVSCDZCLR-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.


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