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GLPG-0974

A free fatty acid receptor-2 (FFA2/GPR43) antagonist
Catalog #: B3292
SKU-Size Size Price Qty
B3292-1 1 mg
$95.00
B3292-5 5 mg
$350.00
More Sizes Get Quote

Product Details

Alternate Name 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid GLPG0974
Peptide Sequence N/A
Appearance White solid
CAS # 1391076-61-1
Molecular Formula C₂₅H₂₅ClN₂O₄S
Molecular Weight 485.0
Purity ≥98% by HPLC
Solubility >40 mg/ml DMSO, >40 mg/ml Ethanol
SMILES O=C(N1CC[[email protected]]1(C)C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)C3=CSC4=C3C=CC=C4
InChi InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1
InChi Key MPMKMQHJHDHPBE-RUZDIDTESA-N
PubChem CID 57520598
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GLPG-0974 is a potent FFA2 (free fatty acid receptor 2) antagonist (IC50 = 9 nM). Displays selectivity for FFA2 over FFA3. GLPG-0974 inhibits acetate-induced migration of isolated human neutrophils in buffer or plasma (IC50s = 27 and 43 nM, respectively), as well as acetate-induced expression of CD11b activation-specific epitope on neutrophils in isolated human whole blood (IC50 = 438 nM).


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