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Glimepiride

Glimepiride is an antidiabetic drug that helps control blood sugar levels.
Catalog #: B1101
SKU-Size Size Price Qty
B1101-10 10 mg
$65.00
B1101-50 50 mg
$245.00
More Sizes Get Quote

Product Details

Alternate Name 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide; Amaryl; Glimperide
Appearance White Solid
CAS # 93479-97-1
Molecular Formula C₂₄H₃₄N₄O₅S
Molecular Weight 490.62
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
InChi InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
InChi Key WIGIZIANZCJQQY-UHFFFAOYSA-N
PubChem CID 3476
MDL Number MFCD00878417
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Glimepiride is a potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC₅₀ of 6.8 nM. Glimepiride displays a higher potency compared to Glibenclamide with respect to stimulation of glucose transport, glucose transporter isoform 4 (GLUT4) translocation and lipid and glycogen synthesis in normal and insulin-resistant adipocytes and in muscle cells, as well as of the potential underlying signaling processes at the molecular level.


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