Product Details
| abID | ab285483 |
|---|---|
| Alternate Name | Glial-Derived Neurotrophic Factor, ATF-1, Astrocyte-derived trophic factor |
| Gene Symbol | GDNF |
| Gene ID | 2668 |
| Accession # | P39905 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from 10 mM Sodium Citrate + 150 mM NaCl, pH 4.0. |
| Molecular Weight | 30.1 kDa |
| Purity by SDS-PAGE | ≥98% |
| Purity by | ≥98% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | The ED₅₀ as determined by the dose-dependent dopamine uptake by rat ventral mesencephalic cultures was found to be in the range of 4-8 ng/ml. |
| Reconstitution Instructions | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human GDNF (Glial-Derived Neurotrophic Factor) is a 30.1 kDa protein that specifically promotes dopamine uptake and survival of midbrain neurons. GDNF is a disslphide-linked homodimer, formed by two identical 134 amino acids subunits.
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