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GDF-15, Human Recombinant

based on 1 citations in multiple journalsGDF-15, Human Recombinant14.1 4
A protein with functions in regulating inflammatory and apoptotic pathways
Catalog #: 4569
SKU-Size Size Price Qty
4569-20 20 μg
4569-100 100 μg
4569-1000 1 mg
More Sizes Get Quote

Product Details

Alternate Name Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein,Prostate differentiation factor
Gene Symbol GDF-15
Gene ID 9518
Accession # Q99988
Source E. coli
Appearance Lyophilized protein
Physical Form Description Recombinant human GDF-15 is lyophilized from a sterile 0.2 micron filtered aqueous solution containing 0.1% trifluoroacetic acid (TFA).
Molecular Weight 12.4 kDa (monomer), 24.8 kDa (dimer)
Purity by SDS-PAGE ≥95%
Endotoxin Level Endotoxin level as measured by LAL analysis is ≤ 1 EU/µg.
Reconstitution Instructions Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile deionized water or a solution of 5 mM acetic acid at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions
Handling Centrifuge the vial prior to opening.
Storage Conditions Lyophilized product is very stable at -20 °C. Reconstituted material should be aliquoted and frozen at -20 °C. It is recommended that a carrier protein (0.1% BSA) be added for long term storage
USAGE For Research Use Only! Not to be used in humans


Growth and differentiation factor 15 (GDF-15) is a TGFβ family member, made by in the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 is a non-glycosylated, disulfide linked homodimer. It is comprised of two identical 120 amino acid monomers and has a total molecular mass of 26.8 kDa.

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Please let us know the difference between cat# 456920 (GDF15, human recombinant) and cat# 4570100 (GDF15D, human recombinant).
The difference is in the amino acid sequence. 4570100 (GDF15D) has a His to an Asp substitution at position 7
Huibin Tang, mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cel, March 2019; 30924297.
Kenji Sunagawa et al., Inhibition of Neuregulin-1/ErbB Signaling in the Rostral Ventrolateral Medulla Leads to Hypertension through Reduced Nitric Oxide Synthesis. Am J Hypertens, Jan 2013; 26: 51 - 57
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