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GDF-15, human recombinant

based on 1 citations in multiple journalsGDF-15, human recombinant14.1 4
A protein with functions in regulating inflammatory and apoptotic pathways
Catalog #: 4569
SKU-Size Size Price Qty
4569-20 20 μg
$260.00
4569-100 100 μg
$645.00
4569-1000 1 mg
$5,735.00
More Sizes Get Quote

Product Details

Alternate Name Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein,Prostate differentiation factor
Gene Symbol GDF-15
Gene ID 9518
Accession # Q99988
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 26.8 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.01 ng/μg
Biological Activity The activity is determined by the inhibition of DU-145 cells and is typically 1-2 µg/mL.
Reconstitution Instructions Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 5 mM acetic acid
Amino Acid Sequence MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Growth and differentiation factor 15 (GDF-15) is a TGFβ family member, made by in the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 is a non-glycosylated, disulfide linked homodimer. It is comprised of two identical 120 amino acid monomers and has a total molecular mass of 26.8 kDa.


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Please let us know the difference between cat# 456920 (GDF15, human recombinant) and cat# 4570100 (GDF15D, human recombinant).
The difference is in the amino acid sequence. 4570100 (GDF15D) has a His to an Asp substitution at position 7
Huibin Tang, mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cel, March 2019; 30924297.
Kenji Sunagawa et al., Inhibition of Neuregulin-1/ErbB Signaling in the Rostral Ventrolateral Medulla Leads to Hypertension through Reduced Nitric Oxide Synthesis. Am J Hypertens, Jan 2013; 26: 51 - 57
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