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GDC-0349

A potent and selective ATP-competitive inhibitor
Catalog #: B1729

In stock

SKU-Size Size Price Qty
B1729-1 1 mg
$95.00
B1729-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name GDC-0349; GDC0349; GDC 0349; RG7603; 1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea; (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
Appearance Solid
CAS # 1207360-89-1
Molecular Formula C₂₄H₃₂N₆O₃
Molecular Weight 452.55
Purity >98%
Solubility DMSO
SMILES CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOCC5C
InChi InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1
InChi Key RGJOJUGRHPQXGF-INIZCTEOSA-N
PubChem CID 59239165
MDL Number MFCD22417087
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki value of 3.8 nM.


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