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A smac mimetic
Catalog #: B1918

In stock

SKU-Size Size Price Qty
B1918-1 1 mg
B1918-5 5 mg

Product Details

Alternate Name (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(2-(oxazol-2-yl)-4-phenylthiazol-5-yl)pyrrolidine-2-carboxamide; CUDC-427
Appearance Crystalline solid
CAS # 1446182-94-0
Molecular Formula C₂₉H₃₆N₆O₄S
Molecular Weight 564.7
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C29H36N6O4S/c1-18(30-2)24(36)32-23(20-12-7-4-8-13-20)29(38)35-16-9-14-21(35)25(37)34-27-22(19-10-5-3-6-11-19)33-28(40-27)26-31-15-17-39-26/h3,5-6,10-11,15,17-18,20-21,23,30H,4,7-9,12-14,16H2,1-2H3,(H,32,36)(H,34,37)/t18-,21?,23-/m0/s1
PubChem CID 71621671
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GDC-0917 (CUDC-427) is a second mitochondrial activator of caspases (Smac) mimetic, a small molecule inhibitor, that mimics Smac, an endogenous antagonist of IAP proteins. GDC-0917 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2.

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