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GDC-0980

A potent PI3K/mTOR kinase inhibitor
Catalog #: 2668
SKU-Size Size Price Qty
2668-1 1 mg
$85.00
2668-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one; apitololisib
Appearance White solid
CAS # 1032754-93-0
Molecular Formula C₂₃H₃₀N₈O₃S
Molecular Weight 498.6
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)C(C)O
InChi InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
InChi Key YOVVNQKCSKSHKT-HNNXBMFYSA-N
PubChem CID 25254071
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). It inhibits PI3Kα/β/δ/γ with IC₅₀ values of 5 nM/27 nM/7 nM/14 nM, respectively and mTOR with Ki of 17 nM. GDC-0980 is highly selective versus others PIKK family kinases. Displays anticancer activity.


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