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GDC-0941

A PI3 Kinase inhibitor
Catalog #: 1623
SKU-Size Size Price Qty
1623-1 1 mg
$150.00
1623-5 5 mg
$520.00
More Sizes Get Quote

Product Details

Alternate Name 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Appearance Off-white solid
CAS # 957054-30-7
Molecular Formula C₂₃H₂₇N₇O₃S₂
Molecular Weight 513.64
Purity ≥99% by HPLC
Solubility DMSO
SMILES CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
InChi InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
InChi Key LHNIIDJUOCFXAP-UHFFFAOYSA-N
PubChem CID 17755052
MDL Number MFCD11616196
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

GDC-0941 is a potent inhibitor of p110α and p110δ (IC₅₀ = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.


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